Modern Physical Methods in Biochemistry

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Experiments in thermodynamics, modern electronic measurements, computer modeling, and data reduction. Experiments in statistical mechanics, chemical kinetics, plasma chemistry, and mass spectrometry. Experiments in molecular spectroscopy, quantum chemistry, and laser-excited chemical and physical processes to illustrate theoretical principles.

Modern physical organic chemistry including chemical bonding, acid-base chemistry, thermochemistry, noncovalent interactions, and introduction to computational chemistry. Modern physical organic chemistry including tools to study reaction mechanisms, kinetic analysis, isotope effects, and qualitative molecular orbital theory. Introduction to group theory for molecular symmetry; syntheses, structures, reactions, and reaction mechanisms of coordination complexes and organometallic complexes.

Bioinorganic chemistry: metals in biological systems; coordination chemistry, reactions, spectroscopy, metalloclusters, and synthetic modeling. Solid-state inorganic chemistry: solid-state structure and its determination; the electrical, magnetic, and mechanical properties of materials and their physical description.

The principles of time-independent quantum mechanics and their application to model atomic and molecular systems. Prereq: CH or equivalent. Molecular structure theory, perturbation theory, time-dependent quantum mechanics, theory of spectra, selection rules.

Experimental spectra of atomic and molecular systems and surfaces. The laws of thermodynamics and their applications, including those to nonideal chemical systems. Molecular basis of thermodynamics.

Chemistry and Biochemistry (CHEM)

Applications to the calculation of the properties of noninteracting and weakly interacting systems. Description and interpretation of the time evolution of chemical systems. Principles of organic-inorganic reaction dynamics; kinetics and mechanisms, linear free-energy relationships, isotope effects, substitution reactions, dynamic behavior of reactive intermediates, electron transfer chemistry.

Principles and applications of stereochemistry; reagents and reactions, with mechanisms, used in contemporary organic synthesis; examples taken from the current literature. Metabolism and metabolic control processes. Energy and sensory transduction mechanisms. Mechanisms and regulation of nucleic acid and protein biosynthesis.

Department of Chemistry & Biochemistry

Other current topics in biochemical genetics. Physical chemical properties of biological macromolecules; forces and interactions to establish and maintain macromolecular conformations; physical bases of spectroscopic, hydrodynamic, and rapid-reaction investigative techniques.

Offered alternate years. Protein and nucleic acid structures and energetics. Structure determination by x-ray crystallography and nuclear magnetic resonance. Computational methods for structural analysis. Seminars offered in biochemistry, chemical physics, materials science, molecular biology, neuroscience, organic-inorganic chemistry, and physical chemistry. Topics include bioorganic and bioinorganic chemistry, computational chemistry, green chemistry, medicinal chemistry, natural products, organometallic chemistry, polymers, catalysis, molecular motors, and spectroscopic methods for structure determination.

Repeatable when topic changes. Topics include enzyme mechanisms, stability and conformation of macromolecules, nucleic acids and nucleic acid protein complexes, conformational analysis of macromolecules, protein and nucleic acid biosynthesis. Preparation and delivery of colloquium-style lectures in organic-inorganic chemistry based on papers from the literature. Repeatable for maximum of 12 credits. Preparation and delivery of colloquium-style lectures in physical chemistry based on papers from the literature. Structured laboratory exercises to perform examples of the various reactions discussed in lectures.

Detailed consideration of enzyme mechanisms, macromolecular structure, protein-nucleic acid interactions, and selected aspects of biological synthesis. Methods of polymer synthesis and characterization; kinetics and mechanisms of the principal polymerization reactions. Introduction to mechanical properties and fabrication techniques. Statistical and thermodynamic models for the equilibrium configuration, conformation, structure, mechanical properties, and phase transitions of polymer solutions, dense melts, liquid crystals.

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Preparation and physical characterization of polymers; emphasis on polymers of commercial interest. Elementary theory of inorganic solids; electronic structures and transport properties of semiconductors. Basic theory of semiconductor devices including diodes, transistors, mosfets, and optoelectronic devices. Solid-state and surface chemistry of inorganic semiconductors as it pertains to microelectronic devices. Design, fabrication, and testing of semiconductor devices with an emphasis on wafer processing and device realization. Successful completion of courses in the core areas of Chemistry provides the necessary academic background for the work experience.

In addition to the current fees for courses in academic study terms, Chemistry Co-op students are assessed an annual administrative fee see the Schedule of Fees. Eligibility to continue in the Co-op program is based on the student's major average and non-major average. A student with a minimum 70 percent major average and a minimum 60 percent non-major average will be permitted to continue. A student with a major average lower than 70 percent will not be permitted to continue in the Chemistry Co-op program, but may continue in the non Co-op Chemistry stream.

For further information, see the Co-op Programs section of the Calendar, and contact the Department of Chemistry. All students in the Co-operative Education program are required to read, sign and adhere to the terms of the Student Regulations Waiver and Co-op Student Manuals brocku. In addition, eligibility to continue in the co-op option is based on the student's major average and non-major average, and the ability to demonstrate the motivation and potential to pursue a professional career.

Each four-month co-operative education work term must be registered. Once students are registered in a co-op work term, they are expected to fulfill their commitment. If the placement accepted is for more than one four-month work term, students are committed to complete all terms. Students may not withdraw from or terminate a work term without permission from the Director, Co-op Program Office.

The requirement for graduation with a Chemistry Honours degree is a minimum 70 percent major average and a minimum 60 percent non-major average.

12222-2020 Undergraduate Calendar

Note: steel-toed safety boots may be required on plant tours. Introduction to Research. A survey of modern theories of reaction rates and mechanisms, classic thermodynamic functions, and an introduction to statistical thermodynamics. Undergraduate students gain hands-on experience in operating modern equipment for separating of complex mixtures, determining molecular structures, and making quantitative measurements. Temperature jump. It deals with fast reaction methods, high performance liquid chromatography of peptides and proteins, fluorescence spectroscopy, neutron and X-ray scattering techniques, and also Raman and resonance spectroscopy which have in recent years been used to an increasing extent in biochemistry. This article's lead section may be too long for the length of the article.

The Chemistry Co-op program designation will be awarded to those students who have honours standing and who have successfully completed a minimum of twelve months of Co-op work experience. The equipment available in the Mackenzie Chown and Cairns Family Health and Bioscience Research Complexes is actively used for both teaching and research. Undergraduate students gain hands-on experience in operating modern equipment for separating of complex mixtures, determining molecular structures, and making quantitative measurements.

Newer equipment is computer-controlled and is connected to the University's Ethernet backbone. Instrumentation includes , and MHz NMR cryospectrometers for high-resolution solution and solids studies. It is equipped with a high performance capillary GC system. A state-of-the-art biotechnology research lab was recently equipped for biochemistry and microbiology work.

This instrumentation is augmented by a range of modern facilities available through the Cool Climate Oenology and Viticulture Institute, which support work in biochemistry, especially work involving proteins, nucleic acids, yeasts and bacteria. In 20 credit degree programs a maximum of eight credits may be numbered 1 alpha 00 to 1 alpha 99; at least three credits must be numbered 2 alpha 90 or above; at least three credits must be numbered 3 alpha 90 or above; and the remaining credits must be numbered 2 alpha 00 or above. In 15 credit degree programs a maximum of eight credits may be numbered 1 alpha 00 to 1 alpha 99; at least three credits must be numbered 2 alpha 90; and the remaining credits must be numbered 2 alpha 00 or above.

In some circumstances, in order to meet university degree and program requirements, more than 15 or 20 credits may be taken. Students admitted to the Chemistry Co-op program must follow an approved program pattern. The most common pattern is listed below. For other approved patterns, consult the Co-op Office. This program differs from the Honours program in that honours standing is not required for entry into year 4, and year 4 does not include the research project and thesis courses CHEM 4F90 and 4F Combined majors should consult the Chair.

Satisfactory completion of the first three years of the Honours program entitles a student to apply for a Pass degree. Consult the Biochemistry calendar entry for a listing of courses and program requirements. Consult the Biotechnology calendar entry for a listing of courses and program requirements. In most of the combined major programs a research project must be successfully completed and a thesis written as part of the requirements for an Honours degree.

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Consult the Biological Sciences entry for a listing of program requirements. Consult the Computer Science entry for a listing of program requirements. Consult the Earth Sciences entry for a listing of program requirements. Students in other disciplines may obtain a minor in chemistry within their degree program by completing the following courses with a minimum 60 percent average:.

Practical Methods of Biochemistry. | The Journal of Physical Chemistry

Under the Agreement, Brock University will admit graduates of Mohawk College who have completed the Chemical Engineering Technology diploma program with a minimum 78 percent overall average to its Honours Bachelor of Science program in Chemistry with 6. Graduate programs emphasize independent research by students in a wide variety of chemical fields reflecting research interests of individual faculty.

For further information, including faculty interests, see the current Graduate Calendar or the Department of Chemistry's website. Note that not all courses are offered in every session. Refer to the applicable term timetable for details. Students must check to ensure that prerequisites are met. Fundamental principles of chemistry.

Topics include atomic structure and the periodic table, names and formulas of chemical compounds, principles of chemical bonding, types of chemical reactions, and basic chemical calculations. Tutorials emphasize the development and practice of problem solving skills.

Lectures, 3 hours per week; lab, tutorial and problems solving session, 3 hours per week. Materials fee required. Stoichiometry, inorganic and organic reactions, quantum mechanics, molecular structure and bonding, solutions and their properties, thermochemistry and gas laws. Lectures, 3 hours per week; tutorial, 1 hour alternating weeks; plus a minimum of five 3-hour labs per term. Molecular structure, shapes, and behaviour of molecules emphasizing organic compounds, bonding and intermolecular interactions, the states of matter, chemical equilibrium, titrations, entropy, free energy, electrochemistry, and reaction rates.

Phase equilibrium; gas phase kinetics; electronic structure of atoms and molecules; interaction of light with matter. Lectures, 3 hours per week; tutorial, 2 hours per week; plus a minimum of six 3-hour labs. Introduction to the principles and techniques of organic chemistry; correlation of reactions and physical properties of organic compounds with structure and energetic concepts. Introduction to applications of spectroscopy in organic chemistry and biochemistry.

Selected experiments in organic preparations and techniques. Lectures, 3 hours per week; tutorial 1. Introduction to aromatic molecules and electrophilic aromatic substitution reactions. Chemistry of natural products, their origin and biological significance. Topics include concepts of carbonyl and carbohydrate chemistry, DNA and an introduction to amino acids and proteins. Selected experiments in organic synthesis, and characterization and analysis. Basic principles of coordination chemistry.

Chemistry and reactions in aqueous solutions; structure and bonding in simple compounds. Introduction to bioinorganic chemistry highlighting the overlap between inorganic chemistry and biology.

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Survey of the periodic table stressing periodicity of chemical behaviour. Introduction to analytical methods such as volumetric methods acid-base, complexometric, precipitation and redox titrations , electroanalytical techniques potentiometry , spectrophotometry, solvent extraction and chromatography. Statistical treatment of analytical data, chemical equilibria, pH, buffers and chemical activities. Physical chemistry as applied to biological sciences. Introductory thermodynamics, kinetics, equilibria, and transport phenomena as applied to proteins, biological membranes and other biological systems.

Laboratory work includes kinetic measurements, equilibrium constant measurements and protein purification and characterization. Undergraduate research project carried out either in the department under the supervision of a faculty member or as an employee in a chemical industry or other suitable laboratory.

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Note: refer to the online guidelines available at brocku. Methods for functional group manipulation including oxidation, reduction and the use of protecting groups in organic chemistry. General methods for carbon-carbon bond formation emphasizing three dimensional structure and mechanism. Modern methods of asymmetric synthesis. Selected experiments in synthetic organic chemistry and the handling of air and water sensitive reagents. May be taken concurrently. The chemistry of amines, heterocyclic and heteroaromatic compounds.

Pericyclic reactions and reactive intermediates. Molecular rearrangements, peptide synthesis and protecting groups, design of organic synthesis. Introduction to organic photochemistry and the chemistry of carbenes. Systematic inorganic and organometallic chemistry of the main group elements, emphasizing structure, bonding and reactivity in inorganic and organometallic compounds. Selected experiments in inorganic and organometallic synthesis; use of modern structural methods for determination of composition, structure and bonding. Magnetic and electronic properties of metal complexes under different coordination geometries and environments.

First row transition metals, their properties, chemical reactivity and applications in materials science, magnetism, optics and nanotechnology. Organometallic compounds of d-block elements and their applications in catalysis. Use of instrumental methods for the determination of structures of molecules. Techniques will include mass spectrometry, nuclear magnetic resonance spectroscopy, covered Fourier transform infrared spectroscopy, visible and UV spectroscopy, computerized data manipulation.

Modern instrumentation and their applications to quantitative analysis of atomic and molecular species. Separation methods such as gas, liquid and supercritical fluid chromatography, and capillary electrophoresis. Techniques such as UV-vis absorption, atomic absorption, atomic emission, atomic fluorescence and mass spectrometry. Schrodinger equation, solution of the harmonic oscillator problem, hydrogen atom, angular momentum theory, variational method with applications to atomic and molecular systems, molecular orbital theory and simple group theory.

Introduction to a procedural programming language. Group theory and theory of electro-magnetic radiation and spectroscopic transitions. Principles and practice of industrial chemistry. Survey of the chemical industry, pollution control, plant design, corrosion and similar topics.

Selected industrial processes will be discussed in detail. Tours of chemical plants and industrial laboratories. Industrial organic chemicals including raw materials, base and commodity chemicals, and chemicals with specialized applications, such as dyes and pigments, fluorophores, agrochemicals, surfactants, and pharmaceuticals. Mechanistic description of the biosynthesis and metabolism of natural products including alkaloids, terpenes and acetate-derived compounds. Chemistry and structure of nucleic acids, proteins, and carbohydrates.

Restriction: open to CHEM single or combined majors with 9. Note: refer to the online guideline available at brocku. Experimental or theoretical research to be carried out under faculty supervision. The thesis incorporates the results of the research in CHEM 4F90 and forms the basis for a seminar to be presented by the student. Tutorials, seminars, special projects or directed readings in an area of chemistry. Restriction: open to CHEM single or combined majors with a minimum of Ensembles, entropy, free energy, statistical mechanics of simple gases and solids, heat capacity, chemical equilibrium, substrate binding, water as a solvent, and polymers and biopolymers.

Principles of light induced processes such as electron, energy and signal transfer and their role in biological systems. Marcus theory, Dexter and Foerster mechanisms of energy transfer. The optical and magnetic resonance spectroscopy of excited states. Structure-based drug design, molecular modelling, conformational search techniques, secondary and tertiary protein structure prediction, quantitative structure activity relationships and bioinformatics.

Organic reaction mechanisms. Named reactions and their use in synthesis. Review of basic physical organic principles. Emphasis on selectivity and stereochemistry in modern synthetic methods including organometallic reactions. Topics include conformational analysis, introduction to transition state theory and the description of stereo and electronic control in organic reactions.

Pertinent applications will be taken from the recent literature. Use of organometallic reagents for organic transformations. Metalation and trans-metalation using organolithium, magnesium, cerium and zinc reagents; stable precursors and reactive intermediates in transition metal catalyzed organic reactions employing palladium, nickel, ruthenium, and other metals. Topics from recent literature involving applications to organic synthesis, emphasizing stereoselectivity.

Principles of toxicology. Key enzymes involved in the metabolism and biotransformation of xenobiotics. Actions of xenbiotics on nucleic acids, proteins and lipids.