An expert panel drawn from all over India, met to discuss and draw guidelines for management of pediatric septic shock that are applicable to resource limited countries. The group evaluated strength … of published data and expert opinion for clinical practice and feasibility of delivery of care at various levels of resource constraints, keeping in view unique patient population and limited availability of equipment and resources.
Evidence has been graded and levels of evidence indicated wherever applicable. The expert group recognized and listed potential barrier to implementation of existing American College of Critical Care Medicine guidelines for treatment of septic shock in resource limited countries, adopted simplified definitions of septic shock, tachycardia, tachypnea and hypotension, and developed step-wise algorithmic approach for treating septic shock.
Evidence based treatment recommendations include early oxygen therapy, fluid resuscitation based on blood pressure, use of dopamine in fluid refractory shock, early use of antibiotics, early intubation and assisted ventilation, correction of hypoglycemia and emphasis on use of physical examination for achieving therapeutic endpoints. Interventions recommended after above steps were based on consensus rather than evidence. These include stress dose steroid therapy, use of vasopressors and inodilators, and central venous pressure and echocardiography to guide fluid and vasoactive drug infusion, which require transfer to a pediatric intensive care unit.
Strict glycemic control is not recommended. Evidence on benefit of several other interventions viz. The expert group observed that further research evaluating individual components of guidelines and relative benefit of each of these interventions in resource limited setting is needed, as also the benefit of adherence with standardized protocol. Pediatric sepsis guidelines suitable for resource limited settings are presented for resource limited settings. Several unresolved issues were identified for further research. Keywords: Children, emergency care, septic shock, fluid resuscitation, vasoactive drugs.
In navigation section. Select this link to jump to content Menu. Search Search. Published between: Published from year: and Published to year: Search syntax help. In content section. Purchase individual online access for 1 year to this journal. The Journal of Pediatric Infectious Diseases is a peer-reviewed medical journal, publishing articles in the field of child infectious diseases.
The journal provides an in-depth update on new subjects and current comprehensive coverage of the latest techniques in diagnosis and treatment of childhood infectious diseases. The following articles will be considered for publication: editorials, original and review articles, rapid communications, case reports, letters to the editor and book reviews.
The aim of the Journal of Pediatric Infectious Diseases is to share and disseminate knowledge between all disciplines that work in the field of pediatric infectious diseases. Recommend this journal Editorial board Submissions. Show: 10 Mark all Add marked to cart Export marked citations. Select this result for bulk action Sepsis and septic shock, global perspectives. Price: EUR Select this result for bulk action Sepsis and septic shock: A global overview. Article Type: Research Article Abstract: Severe sepsis and septic shock are life-threatening diseases in both developed and developing countries and is an important risk factor for morbidity and mortality in all age groups.
Show more Keywords: Severe infectio, sepsis, septic shock, epidemiology, mortality, children DOI: Select this result for bulk action The global neonatal and pediatric sepsis initiative. Article Type: Research Article Abstract: Sepsis and septic shock are major contributors to mortality in children worldwide. Select this result for bulk action Septic shock: Management in emergency department with available resources. Santhanam, Indumathy Article Type: Research Article Abstract: Sepsis and septic shock are associated with significant mortality among children of developing economies.
Show more Keywords: Children, emergency department, fluid resuscitation, septic shock, resource-limited setup DOI: Select this result for bulk action Sepsis in the pediatric intensive care unit. Authors: Singal, Mona Mizuno, Yumiko Skippen, Peter Kissoon, Niranjan Article Type: Research Article Abstract: Early recognition of pediatric severe sepsis and septic shock followed by aggressive protocolized clinical management are the keys to improving mortality outcomes.
Select this result for bulk action Dengue viral infections and shock syndromes: An overview. Show more Keywords: Dengue, dengue hemorrhagic fever, dengue shock syndrome, shock, dengue immunopathogenesis, dengue diagnosis, management of shock, prevention of fluid overload DOI: Select this result for bulk action Hormonal therapies in septic shock.
Select this result for bulk action Immune modulation in sepsis.
Article Type: Research Article Abstract: The vast majority of morbidity and mortality from sepsis can be attributed to the host immune response to infection rather than the infection itself. Select this result for bulk action Plasma exchange therapy in sepsis. Article Type: Research Article Abstract: Sepsis is a systemic inflammatory syndrome in response to an infection. Select this result for bulk action Sepsis and septic shock study in pediatric critical care: An overview of recent Chinese literature.
Show more Keywords: Multiple organ dysfunction syndrome, pediatric intensive care unit, respiratory failure, sepsis, septic shock, systemic inflammatory response syndrome DOI: Select this result for bulk action Neonatal sepsis and septic shock: Current trends in epidemiology and management. There are no illustrations and only a small number of line drawings and tables.
The table of contents provides chapter title and authorship. A subject index of six pages concludes. Twelve chapters are included in the approximately pages of this attractive book. This book provides a concise update on many of the treatment strategies at the center of contemporary clinical trials in sepsis.
Other strategies for manipulating the inflammatory response in the setting of sepsis include the use of corticosteroids, immunonutrition, extracorporeal therapies, intravenous immunoglobulin, and the modulation of pre-existing immunosuppressive drugs. Regarding potential harm, early parenteral nutrition is expected to prevent various complications arising from an increased caloric deficit, particularly in malnutrition. However, the strength of this evidence was considered to be weak, and albumin use in this context was found to have only a limited effect. In this report, management of sepsis, severe sepsis and septic shock as well as other complications were carried out in both multicenter or single center studies, mostly according to international definitions and recommendations for sepsis and septic shock. As a result, these guidelines recommend against the routine use of combination therapies. Use of vascular inotropic drugs to maintain blood pressure.
Presentations on the new genetics of infection and the continuing question of the role of steroids in sepsis are particularly helpful. The continuing problems of antiinflammatory trials in sepsis are also discussed. You may be trying to access this site from a secured browser on the server.
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