Gene Engineering in Endocrinology

How Has Genetic Testing Changed the Diagnosis of Short Stature in Children?
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CRISPR Explained

After completing his residency in internal medicine and fellowship in endocrinology at Northwestern McGaw Medical Center, Dr. Huang has stayed on faculty at this prestigious academic medica The department works toward an environment of inclusion and support through the Diversity and Cultural Affairs Council and through several dedicated events and initiatives. Learn More. We offer a wide range of resources, mentorship opportunities and training to help our residents and fellows excel as physician-scientists. Explore all of the resources and hear from housestaff who are making research a major part of their career development plans.

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  • Genetic testing can influence treatment aid, discovery of endocrine disorders.

Department of Medicine Feinberg. Education Learn More. Lisa M Neff. Assistant Professor of Medicine Endocrinology My primary research is designed to investigate factors which may be involved in the process of metabolic adaptation to weight loss in individuals who have become overweight or obese. Thomas L Pitts. Clinical Associate Professor of Medicine Endocrinology Research efforts have centered on diabetes detection and management including participation the diabetes prevention trial, Phase 3 and 4 efficacy trials for diabetes treatment. M Geoffrey Hayes. Grazia Aleppo.

Professor of Medicine Endocrinology My primary clinical interest is Diabetes, especially Diabetes and Technology and the application of the use of Insulin pump Therapy and real Time Continuous glucose monitoring sensor therapy to Diabetes type 1 and Diabetes type 2.

Genetic testing can influence treatment aid, discovery of endocrine disorders

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Note: Please don't include any URLs in your comments, as they will be removed upon submission. We do not store details you enter into this form. Please see our privacy policy for more information. Click here to return to the Medical News Today home page. Study co-author Dr. Bruno Doiron, Ph. Type 1 diabetes is estimated to affect around 1.

Onset of the condition is most common in childhood, but it can arise at any age. In type 1 diabetes, the immune system destroys the insulin-producing beta cells of the pancreas. Insulin is the hormone that regulates blood glucose levels. As a result, blood glucose levels become too high. There is currently no cure for type 1 diabetes; the condition is managed through diet and insulin therapy. However, in recent years, researchers have investigated replacing beta cells as a means of eradicating type 1 diabetes once and for all.

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Doiron and colleagues have taken a different approach with their new study. The team reveals how they used a method called gene transfer to coax other pancreatic cells into producing insulin. Using this technique, the researchers have managed to cure type 1 diabetes in mice, bringing us one step closer to curing the condition in humans. The gene transfer technique - called Cellular Networking, Integration and Processing - involves introducing specific genes into the pancreas using a virus as a vector.

The team notes that beta cells are rejected in patients with type 1 diabetes. With the gene transfer method, the newly introduced genes encourage non-beta cells to produce insulin, without any side effects.

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During the past five to ten years, a variety of tools has been developed in the disciplines of both gene engineering, and molecular and structural biology. Endocrinology is an intuitive setting in which to consider the principles of genetic testing because endocrine disorders are due to defects in circumscribed.

Ralph DeFronzo, chief of the Division of Diabetes. Upon testing their technique on mouse models of type 1 diabetes, the researchers found that they were able to induce long-term insulin secretion and blood glucose regulation, with no adverse side effects. We cured mice for 1 year without any side effects.

Biochemistry, Metabolism, and Endocrinology Program (6029)

That's never been seen. But it's a mouse model, so caution is needed. We want to bring this to large animals that are closer to humans in physiology of the endocrine system. Importantly, the researchers point out that the gene transfer therapy only releases insulin in response to blood sugar, so it has the potential to transform current treatments for type 1 diabetes.