Organic Cation Transporters: Integration of Physiology, Pathology, and Pharmacology

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http://t2.swirlonthru.com/8250.php This chapter reviews the endocrine and metabolic pathways that influence the pharmacokinetics as well as the toxicity of organic cations. Endocrine and metabolic regulation of transporters for organic cations.

N2 - The disposition of organic cations in the liver and kidneys are under a dynamic regulation by the endocrine and metabolic systems of the body. AB - The disposition of organic cations in the liver and kidneys are under a dynamic regulation by the endocrine and metabolic systems of the body.

Introduction to the Cellular Transport of Organic Cations

Abstract The disposition of organic cations in the liver and kidneys are under a dynamic regulation by the endocrine and metabolic systems of the body. Fingerprint Cations. Endocrine System.

What is P-glycoprotein?

OCT2 transports monoamine neurotransmitters, thereby participating in the regulation of interstitial and intracellular concentrations of monoamine neurotransmitters and cationic drugs. Pathology: OCT2 transporter contributes to renal drug uptake, clearance and transporter — mediated drug interactions.

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Recommended Reviews: Koepsell, H. Endou, The SLC22 drug transporter family. Pflugers Arch, J Pharmacol Exp Ther, Skickas inom vardagar.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Transporters

This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems.

The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts.

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