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Saudi Pharm J. Grasset, P. Keywords: niosomes, transdermal, permeation, enhancer, drug delivery Introduction This review provides a brief overview of issues related to niosomes by explaining their chemical composition, structure, advantages, and applications, makes general remarks on niosomes as percutaneous permeation enhancers, and discusses the findings of investigations done over the past 5 years on niosomal drug delivery systems for transdermal applications. Meneghetti, J. Incorporating receptor targeting or using bioresponsive linkers to release PEG have proven useful to overcome these intracellular barriers to efficient delivery [ ].
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Itraconazole-loaded nanostructured lipid carriers NLC for pulmonary treatment of aspergillosis in falcons. Development, optimization and evaluation of surfactant-based pulmonary nanolipid carrier system of paclitaxel for the management of drug resistance lung cancer using Box-Behnken design. Nanoparticle-mediated pulmonary drug delivery: a review. Int J Mol Sci. Potential of solid lipid nanoparticles in brain targeting.
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Arch Pharm Res. This article has been cited by 1 Nanocarriers for effective delivery of benznidazole and nifurtimox in the treatment of chagas disease: A review Eva C. Seremeta,Giselle R. Bedogni,Nora B. Okulik,Claudio J. Salomon Acta Tropica. Ketabat,Claudio J. Pundir,Claudio J. Mohabatpour,Claudio J. Lobanova,Claudio J.
Koutsopoulos,Claudio J. Hadjiiski,Claudio J. Chen,Claudio J. Papagerakis,Claudio J. Papagerakis Pharmaceutics. Narayan Reddy Maharjan,V. Narayan Reddy Pangeni,V. Narayan Reddy Jha,V. Narayan Reddy Choi,V. Narayan Reddy Chang,V. Narayan Reddy Park,V. Narayan Reddy Byun Pharmaceutics. Ardila Vargas,Maritza A. Rojas Cardozo,Claudia E. Mora Huertas Revista Brasileira de Farmacognosia. Advanced Search Users Online: Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages.
Res Pharma Sci ; Types of Lipid Nanoparticles. Figure 1: Schematic view of the solid lipid nanoparticle SLN and nanostructured lipid carriers NLCs showing the drug location within the lipid matrix. Click here to view. Methods of Lipid Nano-Particles Preparation. Table 1: Different loaded active compound and routes of administration of lipid nanoparticles. Table 2: Lipid nanoparticles advantages and disadvantages as topical drug delivery systems.
Table 3: Lipid nanoparticles advantages and disadvantages as oral drug delivery systems. Table 4: Lipid nanoparticles advantages and disadvantages as ocular drug delivery systems. Table 5: Lipid nanoparticles advantages and disadvantages as parenteral drug delivery systems. Table 6: Lipid nanoparticles advantages and disadvantages as pulmonary drug delivery systems. Table 7: Lipid nanoparticles advantages and disadvantages as brain drug delivery systems. This article has been cited by. Nanocarriers for effective delivery of benznidazole and nifurtimox in the treatment of chagas disease: A review.
Eva C. High MW macromolecular materials proteins, polysaccharides and synthetic polymers usually exist in the form of long thread-like or branched-chain molecules; these materials often exhibit a considerable mechanical strength and durability not possible with corpuscular or laminar particles All dispersed particles spontaneously acquire a surface electrical charge when brought into contact with a polar medium i.
For all liquid-liquid interfaces and most normal colloidal dispersions Mechanism 1 is of little significance; an exception is metal sols i. Mechanism 2 is commonly observed with carboxylic acid- and amine-containing surfaces i. Lyophobic colloidal dispersions i. Ionic solids i. Mechanism 5 arises because most crystal lattices are anisotropic; it is the cause of amphoteric hydroxyl groups in oxides, including silicas Mechanism 6, isomorphous substitution, a more extreme case of Mechanism 5, occurs in alumino-silicate clay materials i.
Nanosilver particles can be found in FDA-approved wound dressings. Bioactive ceramic material based on mixtures of nanosize zirconia and hydoxyapatite are in the development stage for orthopedic weight-bearing implants; one major advantage of nanoparticles is a vast improvement in sintering behavior. The challenge for traditional pharmaceutical companies is to deliver the right therapeutic to the right target with no, or minimal, side effects and ideally at reduced cost.
Nanotechnology may provide improved, differentiated products for all common routes of administration - oral, injection, transdermal, transmucosal, ocular, pulmonary and implant. Particle Sciences is a leading integrated provider of formulation and analytic services and both standard and nanotechnology approaches to drug development and delivery.
Particle Sciences transforms your discovery into a clinic-ready product. By working with us, you can:. Call us today About Us Management Team Employment. Nanotechnology: New Name, Old Science Particle Sciences - Technical Brief: Volume 8 PDF Version Introduction Colloidal phenomena are encountered in everyday materials polymers, plastics, and rubber, agrochemicals, pharmaceuticals and cosmeceuticals, paper, foodstuffs, fabrics, textiles, and detergents and technologies nucleation and precipitation, liquid crystals, chromatography and ion-exchange, flotation, and heterogeneous catalysis.
Nanotechnology In , the FDA issued its Nanotechnology Task Force Report 1 in which nanotechnology is defined as the ability to measure, see, manipulate and manufacture things usually between one and nanometers. The Importance of the Colloidal State The characteristic feature of colloid science lies in the importance of: Particle size Particle shape and flexibility Surface chemical and electrical properties The particles in a colloidal dispersion are sufficiently large for a well-defined surface of separation, an interface, to exist between the particles and the medium 3.
Particle Size The particle size distribution PSD directly affects the bioavailability of active pharmaceutical ingredients APIs and the safety of intravenous lipid emulsions.