Colloids in Drug Delivery

Recent Colloids and Surfaces B: Biointerfaces Articles
Free download. Book file PDF easily for everyone and every device. You can download and read online Colloids in Drug Delivery file PDF Book only if you are registered here. And also you can download or read online all Book PDF file that related with Colloids in Drug Delivery book. Happy reading Colloids in Drug Delivery Bookeveryone. Download file Free Book PDF Colloids in Drug Delivery at Complete PDF Library. This Book have some digital formats such us :paperbook, ebook, kindle, epub, fb2 and another formats. Here is The CompletePDF Book Library. It's free to register here to get Book file PDF Colloids in Drug Delivery Pocket Guide. Clinical application of high-intensity focused ultrasound in cancer therapy. J Cancer. Thermal ablation of tumours: Biological mechanisms and advances in therapy. Pulsed cavitational ultrasound: a noninvasive technology for controlled tissue ablation histotripsy in the rabbit kidney. J Urol. Histotripsy of the prostate: dose effects in a chronic canine model.

Drug and gene delivery across the blood-brain barrier with focused ultrasound. J Control Release. Thermal combination therapies for local drug delivery by magnetic resonance-guided high-intensity focused ultrasound. Assessment of gold nanoparticle-mediated-enhanced hyperthermia using mr-guided high-intensity focused ultrasound ablation procedure.

Nano Lett. High-intensity focused ultrasound- and radiation therapy-induced immuno-modulation: comparison and potential opportunities. Hollow iron-silica nanoshells for enhanced high intensity focused ultrasound. J Surg Res. Microbubbles from gas-generating perfluorohexane nanoemulsions for targeted temperature-sensitive ultrasonography and synergistic HIFU ablation of tumors.

Adv Mater. Nanoparticle-mediated acoustic cavitation enables high intensity focused ultrasound ablation without tissue heating. Ultrasound-mediated diagnosis and therapy based on ultrasound contrast agents. Small Methods. Nanobiotechnology promotes noninvasive high-intensity focused ultrasound cancer surgery.

Adv Healthc Mater. Trimodal therapy: Combining hyperthermia with repurposed Bexarotene and ultrasound for treating liver cancer. ACS Nano. In situ transfection by controlled release of lipoplexes using acoustic droplet vaporization. Noninvasive targeted transcranial neuromodulation via focused ultrasound gated drug release from nanoemulsions. Biomimetic acoustically-responsive vesicles for theranostic applications. Materials chemistry of nanoultrasonic biomedicine.

State-of-the-art materials for ultrasound-triggered drug delivery. Adv Drug Deliv Rev. Echogenic nanoparticles for ultrasound technologies: Evolution from diagnostic imaging modality to multimodal theranostic agent. Nano Today. Curie J, Curie P. Contractions and expansions produced by voltages in hemihedral crystals with inclined faces.

Comptes Rendus. The history of ultrasound. Surgical Clinics.

Colloids and Surfaces B: Biointerfaces

The physical and biological effects of high-frequency sound-waves of great intensity. Phil Mag. Gruetzmacher J. Piezoelektrischer Kristall mit Ultraschallkonvergenz. Z Physik. A new method for the generation and use of focused ultrasound in experimental biology. J Gen Physiol. Ultrasonic lesions in the mammalian central nervous system.

Haar GT, Coussios C. High intensity focused ultrasound: physical principles and devices. Int J Hyperthermia. High-intensity focused ultrasound: current potential and oncologic applications. Jolesz FA. MRI-guided focused ultrasound surgery. Annu Rev Med. Leighton TG. What is ultrasound? Prog Biophys Mol Biol. Three-MHz ultrasound heats deeper into the tissues than originally theorized.

J Athl Train. Physical mechanisms of the therapeutic effect of ultrasound a review. Acoust Phys. Cost-effective assembly of a basic fiber-optic hydrophone for measurement of high-amplitude therapeutic ultrasound fields. J Acoust Soc Am. Measurement of high intensity focused ultrasound fields by a fiber optic probe hydrophone. Preston RC. Output measurements for medical ultrasound. Berlin, Germany: Springer-Verlag. The chemical history of a bubble. Acc Chem Res. Muratore R.

AIP Conference Proceedings. The safety and feasibility of extracorporeal high-intensity focused ultrasound HIFU for the treatment of liver and kidney tumours in a Western population. Br J Cancer. Development of a nationally representative coordinated registry network for prostate ablation technologies. Histotripsy methods in mechanical disintegration of tissue: towards clinical applications.

Mechanical high-intensity focused ultrasound destruction of soft tissue: working mechanisms and physiologic effects. High-intensity focused ultrasound in the treatment of breast tumours. Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model. Histotripsy liquefaction of large hematomas.

Nanodroplet-mediated histotripsy for image-guided targeted ultrasound cell ablation. Refining histotripsy: defining the parameter space for the creation of nonthermal lesions with high intensity, pulsed focused ultrasound of the in vitro kidney. Acceleration of ultrasound thermal therapy by patterned acoustic droplet vaporization. State-of-the-art of microbubble-assisted blood-brain barrier disruption. Efficient and controllable thermal ablation induced by short-pulsed HIFU sequence assisted with perfluorohexane nanodroplets.

Ultrason Sonochem. Targeted drug delivery with focused ultrasound-induced blood-brain barrier opening using acoustically-activated nanodroplets. Pardridge WM. Blood-brain barrier drug targeting: the future of brain drug development. Mol Interv.

4.2. Phase Change Fluorocarbon Droplets

The blood-brain barrier: bottleneck in brain drug development. Progress and problems in the application of focused ultrasound for blood-brain barrier disruption. Effects of high intensity ultrasound on the central nervous system of the cat. J Comp Neuro. Histologic effects of high intensity pulsed ultrasound exposure with subharmonic emission in rabbit brain in vivo.

Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. MRI detection of the thermal effects of focused ultrasound on the brain. Ultrasound contrast agents: properties, principles of action, tolerance, and artifacts. Eur Radiol. Bioeffects considerations for diagnostic ultrasound contrast agents.

J Ultrasound Med. Injectable microbubbles as contrast agents for diagnostic ultrasound imaging: the key role of perfluorochemicals. Angew Chem Int Ed. Stride E, Saffari N. Microbubble ultrasound contrast agents: a review. Proc Inst Mech Eng H.

Colloidal Drug Delivery Systems: Current Status and Future Directions

Summary. Colloidal drug delivery systems present a range of therapeutic benefits in the treatment of a number of challenging conditions, allowing researchers to. The field of neurodegenerative diseases have lately experienced significant advances. Despite that, we are still far from achieving the recovery of the patients.

Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery. Annu Rev Biomed Eng. Therapeutic applications of lipid-coated microbubbles. A microbubble agent improves the therapeutic efficiency of high intensity focused ultrasound: a rabbit kidney study. Urol Res. The use of a micro-bubble agent to enhance rabbit liver destruction using high intensity focused ultrasound.

Targeted delivery of microbubbles and nanobubbles for image-guided thermal ablation therapy of tumors. Expert Rev Med Devices. Nonthermal ablation in the rat brain using focused ultrasound and an ultrasound contrast agent: long-term effects. J Neurosurg. Ultrasonic cavitation-enabled treatment for therapy of hypertrophic cardiomyopathy: Proof of principle.

Tachibana K, Tachibana S. Albumin microbubble echo-contrast material as an enhancer for ultrasound accelerated thrombolysis. In situ conversion of porphyrin microbubbles to nanoparticles for multimodality imaging. Nat Nanotech. Nanoparticles formed by acoustic destruction of microbubbles and their utilization for imaging and effects on therapy by high intensity focused ultrasound.

Ultrasound and microbubble guided drug delivery: mechanistic understanding and clinical implications. Curr Pharm Biotechnol. Enhancement of focused ultrasound with microbubbles on the treatments of anticancer nanodrug in mouse tumors. Spatially uniform tumor treatment and drug penetration by regulating ultrasound with microbubbles. Ultrasound-induced cavitation enhances the delivery and therapeutic efficacy of an oncolytic virus in an in vitro model. Facile one-pot synthesis of polymer-phospholipid composite microbubbles with enhanced drug loading capacity for ultrasound-triggered therapy.

Soft Matter. Acoustically-active microbubbles conjugated to liposomes: characterization of a proposed drug delivery vehicle. Journal of Controlled Release. Paclitaxel-liposome-microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers. Self-assembled liposome-loaded microbubbles: The missing link for safe and efficient ultrasound triggered drug-delivery. Microbubble gas volume: A unifying dose parameter in blood-brain barrier opening by focused ultrasound. McMahon D, Hynynen K. Acute inflammatory response following increased blood-brain barrier permeability induced by focused ultrasound is dependent on microbubble dose.

Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound. Nat Commun. Disrupting the blood-brain barrier by focused ultrasound induces sterile inflammation. Quantification of transient increase of the blood-brain barrier permeability to macromolecules by optimized focused ultrasound combined with microbubbles. Int J Nanomedicine. MRI-guided targeted blood-brain barrier disruption with focused ultrasound: Histological findings in rabbits. Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles.

  1. Monzer Fanun (Ed.): Colloids in Drug Delivery | SpringerLink.
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Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier. Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium.

Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment. SPIO-conjugated, doxorubicin-loaded microbubbles for concurrent MRI and focused-ultrasound enhanced brain-tumor drug delivery. Targeted shRNA-loaded liposome complex combined with focused ultrasound for blood brain barrier disruption and suppressing glioma growth.

Cancer Lett. Ultrasound-triggered effects of the microbubbles coupled to gdnf plasmid-loaded pegylated liposomes in a rat model of Parkinson's disease. Front Neurosci. Folate-conjugated gene-carrying microbubbles with focused ultrasound for concurrent blood-brain barrier opening and local gene delivery.

Localized delivery of curcumin into brain with polysorbate modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy. A multitheragnostic nanobubble system to induce blood-brain barrier disruption with magnetically guided focused ultrasound. Localized delivery of low-density lipoprotein docosahexaenoic acid nanoparticles to the rat brain using focused ultrasound.

Enhancing glioblastoma treatment using cisplatin-gold-nanoparticle conjugates and targeted delivery with magnetic resonance-guided focused ultrasound. MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound. Novel focused ultrasound gene therapy approach noninvasively restores dopaminergic neuron function in a rat Parkinson's disease model.

Efficient blood-brain barrier opening in primates with neuronavigation-guided ultrasound and real-time acoustic mapping. Sci Rep. The effect of lipid monolayer in-plane rigidity on in vivo microbubble circulation persistence. Effect of surface architecture on in vivo ultrasound contrast persistence of targeted size-selected microbubbles. High-intensity focused ultrasound ablation enhancement in vivo via phase-shift nanodroplets compared to microbubbles. J Ther Ultrasound. Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits.

Phase-shift perfluorocarbon agents enhance high intensity focused ultrasound thermal delivery with reduced near-field heating. Phase-change contrast agents for imaging and therapy. Curr Pharm Des. Contrast-enhanced ultrasound imaging and in vivo circulatory kinetics with low-boiling-point nanoscale phase-change perfluorocarbon agents. Acoustic droplet vaporization for therapeutic and diagnostic applications. Zhang P, Porter T. An in vitro study of a phase-shift nanoemulsion: a potential nucleation agent for bubble-enhanced HIFU tumor ablation.

Superparamagnetic iron oxide and drug complex-embedded acoustic droplets for ultrasound targeted theranosis. Nanoparticle-enhanced synergistic HIFU ablation and transarterial chemoembolization for efficient cancer therapy. Noninvasive ablation of prostate cancer spheroids using acoustically-activated nanodroplets. Mol Pharm. Development of nanodroplets for histotripsy-mediated cell ablation. Cavitation-enhanced MR-guided focused ultrasound ablation of rabbit tumors in vivo using phase shift nanoemulsions.

Phys Med Biol. High-intensity focused ultrasound sonothrombolysis: the use of perfluorocarbon droplets to achieve clot lysis at reduced acoustic power. High-intensity focused ultrasound HIFU for dissolution of clots in a rabbit model of embolic stroke. PLoS One. Mechanical bioeffects of acoustic droplet vaporization in vessel-mimicking phantoms.

Incidence and clinical significance of distal embolization during percutaneous interventions involving the superficial femoral artery. J Vasc Surg. Incidence and clinical significance of distal embolization during primary angioplasty for acute myocardial infarction. Eur Heart J. Distal embolization during primary angioplasty: Histopathologic features and predictability. Am Heart J. Microemboli may link spreading depression, migraine aura, and patent foramen ovale.

Ann Neurol. Reduced clot debris size using standing waves formed via high intensity focused ultrasound. Appl Phys Lett. Noninvasive thrombolysis using pulsed ultrasound cavitation therapy - histotripsy. In vitro and in vivo high intensity focused ultrasound thrombolysis.

Invest Radiol. Dependence of pulsed focused ultrasound induced thrombolysis on duty cycle and cavitation bubble size distribution. Ultrasonics Sonochem. Sonographic enhancement of renal cortex by contrast media. Parenchymal enhancement and tumor visualization using a new sonographic contrast agent. Towards aberration correction of transcranial ultrasound using acoustic droplet vaporization. Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Cancer Res. Exploiting the enhanced permeability and retention effect for tumor targeting. Drug Discov Today. Phase-shift, targeted nanoparticles for ultrasound molecular imaging by low intensity focused ultrasound irradiation. Polypyrrole-coated perfluorocarbon nanoemulsions as a sono-photoacoustic contrast agent. Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging. Subwavelength far-field ultrasound drug-delivery. Rapoport N. Phase-shift, stimuli-responsive perfluorocarbon nanodroplets for drug delivery to cancer. Wiley Interdiscip Rev Nanomed Nanobiotechnol.

Bull JL. Cardiovascular bubble dynamics. Crit Rev Biomed Eng. Phase behavior of mixed lipid monolayers on perfluorocarbon nanoemulsions and its effect on acoustic contrast. RSC Adv. Selective vaporization of superheated nanodroplets for rapid, sensitive, acoustic biosensing. Tracking perfluorocarbon nanoemulsion delivery by 19f mri for precise high intensity focused ultrasound tumor ablation.

Chem Rev.

Photoacoustic and ultrasound imaging using dual contrast perfluorocarbon nanodroplets triggered by laser pulses at nm. Biomed Opt Express. J Mater Chem B. Concurrent anti-vascular therapy and chemotherapy in solid tumors using drug-loaded acoustic nanodroplet vaporization. Acta Biomater. Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions.

Size-modulable nanoprobe for high-performance ultrasound imaging and drug delivery against cancer. Ultrasound-triggered phase-transition cationic nanodroplets for enhanced gene delivery. Acoustic cavitation-mediated delivery of small interfering ribonucleic acids with phase-shift nano-emulsions. Delivery of water-soluble drugs using acoustically triggered perfluorocarbon double emulsions.

Pharm Res. Microfluidic fabrication of perfluorohexane-shelled double emulsions for controlled loading and acoustic-triggered release of hydrophilic agents. A novel nested liposome drug delivery vehicle capable of ultrasound triggered release of its payload. Theranostic performance of acoustic nanodroplet vaporization-generated bubbles in tumor intertissue.

Exploiting tumour hypoxia in cancer treatment. Targeting hypoxia in cancer therapy. Ultrasound-activated decafluoropentane-cored and chitosan-shelled nanodroplets for oxygen delivery to hypoxic cutaneous tissues. Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy.

Ultrasound triggered tumor oxygenation with oxygen-shuttle nanoperfluorocarbon to overcome hypoxia-associated resistance in cancer therapies. Stylianopoulos T, Jain RK. Design considerations for nanotherapeutics in oncology. Jain RK, Stylianopoulos T.

Authors and Affiliations

Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers. Antibiotic-free nanotherapeutics: ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors. Physicochemical characterization of sildenafil-loaded solid lipid nanoparticle dispersions SLN for pulmonary application. Pulmonary delivery of tobramycin-loaded nanostructured lipid carriers for Pseudomonas aeruginosa infections associated with cystic fibrosis.


Saudi Pharm J. Grasset, P. Keywords: niosomes, transdermal, permeation, enhancer, drug delivery Introduction This review provides a brief overview of issues related to niosomes by explaining their chemical composition, structure, advantages, and applications, makes general remarks on niosomes as percutaneous permeation enhancers, and discusses the findings of investigations done over the past 5 years on niosomal drug delivery systems for transdermal applications. Meneghetti, J. Incorporating receptor targeting or using bioresponsive linkers to release PEG have proven useful to overcome these intracellular barriers to efficient delivery [ ].

Solid lipid nanoparticles for sustained pulmonary delivery of Yuxingcao essential oil: Preparation, characterization and in vivo evaluation. Nebulized solid lipid nanoparticles for the potential treatment of pulmonary hypertension via targeted delivery of phosphodiesteraseinhibitor. Smart lipid nanoparticles containing levofloxacin and DNase for lung delivery. Design and characterization. Solid lipid nanoparticles SLN and nanostructured lipid carriers NLC for pulmonary application: a review of the state of the art.

Itraconazole-loaded nanostructured lipid carriers NLC for pulmonary treatment of aspergillosis in falcons. Development, optimization and evaluation of surfactant-based pulmonary nanolipid carrier system of paclitaxel for the management of drug resistance lung cancer using Box-Behnken design. Nanoparticle-mediated pulmonary drug delivery: a review. Int J Mol Sci. Potential of solid lipid nanoparticles in brain targeting.

ApoE-modified solid lipid nanoparticles: A feasible strategy to cross the blood-brain barrier. Lipid nanoparticles for brain targeting I. Formulation optimization. Solid lipid nanoparticles for targeted brain drug delivery. Lipid nanoparticles for brain targeting II. Technological characterization. Lipid nanoparticles for brain targeting III. Long-term stability and in vivo toxicity. Solid lipid nanoparticles as vehicles of drugs to the brain: current state of the art. In vitro evaluation of idebenone-loaded solid lipid nanoparticles for drug delivery to the brain.

Brain targeting of risperidone-loaded solid lipid nanoparticles by intranasal route. J Drug Target ;19 6 J Drug Deliv. Preparation and characterization of fenofibrate-loaded nanostructured lipid carriers for oral bioavailability enhancement. Nanostructured lipid carriers: An emerging platform for improving oral bioavailability of lipophilic drugs. Int J Pharm Investig. The use of nanoparticles as a promising therapeutic approach in cancer immunotherapy.

Colloidal capsules: nano- and microcapsules with colloidal particle shells

Artif Cells Nanomed Biotechnol. Attama AA. Recent Pat Drug Deliv Formul. Selvamuthukumar S, Velmurugan R. Nanostructured lipid carriers: a potential drug carrier for cancer chemotherapy. Lipids Health Dis. Prasad D, Chauhan H. Nanotoxicity of Polymeric and Solid Lipid Nanoparticles. Sutariya VB, Pathak Y, editors. Biointeractions of Nanomaterials. Florida: CRC Press; Lung-targeting delivery of dexamethasone acetate loaded solid lipid nanoparticles.

Arch Pharm Res. This article has been cited by 1 Nanocarriers for effective delivery of benznidazole and nifurtimox in the treatment of chagas disease: A review Eva C. Seremeta,Giselle R. Bedogni,Nora B. Okulik,Claudio J. Salomon Acta Tropica. Ketabat,Claudio J. Pundir,Claudio J. Mohabatpour,Claudio J. Lobanova,Claudio J.

Koutsopoulos,Claudio J. Hadjiiski,Claudio J. Chen,Claudio J. Papagerakis,Claudio J. Papagerakis Pharmaceutics. Narayan Reddy Maharjan,V. Narayan Reddy Pangeni,V. Narayan Reddy Jha,V. Narayan Reddy Choi,V. Narayan Reddy Chang,V. Narayan Reddy Park,V. Narayan Reddy Byun Pharmaceutics. Ardila Vargas,Maritza A. Rojas Cardozo,Claudia E. Mora Huertas Revista Brasileira de Farmacognosia. Advanced Search Users Online: Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages.

Recent Colloids and Surfaces B: Biointerfaces Articles

Res Pharma Sci ; Types of Lipid Nanoparticles. Figure 1: Schematic view of the solid lipid nanoparticle SLN and nanostructured lipid carriers NLCs showing the drug location within the lipid matrix. Click here to view. Methods of Lipid Nano-Particles Preparation. Table 1: Different loaded active compound and routes of administration of lipid nanoparticles. Table 2: Lipid nanoparticles advantages and disadvantages as topical drug delivery systems.

Table 3: Lipid nanoparticles advantages and disadvantages as oral drug delivery systems. Table 4: Lipid nanoparticles advantages and disadvantages as ocular drug delivery systems. Table 5: Lipid nanoparticles advantages and disadvantages as parenteral drug delivery systems. Table 6: Lipid nanoparticles advantages and disadvantages as pulmonary drug delivery systems. Table 7: Lipid nanoparticles advantages and disadvantages as brain drug delivery systems. This article has been cited by. Nanocarriers for effective delivery of benznidazole and nifurtimox in the treatment of chagas disease: A review.

Eva C. High MW macromolecular materials proteins, polysaccharides and synthetic polymers usually exist in the form of long thread-like or branched-chain molecules; these materials often exhibit a considerable mechanical strength and durability not possible with corpuscular or laminar particles All dispersed particles spontaneously acquire a surface electrical charge when brought into contact with a polar medium i.

For all liquid-liquid interfaces and most normal colloidal dispersions Mechanism 1 is of little significance; an exception is metal sols i. Mechanism 2 is commonly observed with carboxylic acid- and amine-containing surfaces i. Lyophobic colloidal dispersions i. Ionic solids i. Mechanism 5 arises because most crystal lattices are anisotropic; it is the cause of amphoteric hydroxyl groups in oxides, including silicas Mechanism 6, isomorphous substitution, a more extreme case of Mechanism 5, occurs in alumino-silicate clay materials i.

Nanosilver particles can be found in FDA-approved wound dressings. Bioactive ceramic material based on mixtures of nanosize zirconia and hydoxyapatite are in the development stage for orthopedic weight-bearing implants; one major advantage of nanoparticles is a vast improvement in sintering behavior. The challenge for traditional pharmaceutical companies is to deliver the right therapeutic to the right target with no, or minimal, side effects and ideally at reduced cost.

Nanotechnology may provide improved, differentiated products for all common routes of administration - oral, injection, transdermal, transmucosal, ocular, pulmonary and implant. Particle Sciences is a leading integrated provider of formulation and analytic services and both standard and nanotechnology approaches to drug development and delivery.

Particle Sciences transforms your discovery into a clinic-ready product. By working with us, you can:. Call us today About Us Management Team Employment. Nanotechnology: New Name, Old Science Particle Sciences - Technical Brief: Volume 8 PDF Version Introduction Colloidal phenomena are encountered in everyday materials polymers, plastics, and rubber, agrochemicals, pharmaceuticals and cosmeceuticals, paper, foodstuffs, fabrics, textiles, and detergents and technologies nucleation and precipitation, liquid crystals, chromatography and ion-exchange, flotation, and heterogeneous catalysis.

Nanotechnology In , the FDA issued its Nanotechnology Task Force Report 1 in which nanotechnology is defined as the ability to measure, see, manipulate and manufacture things usually between one and nanometers. The Importance of the Colloidal State The characteristic feature of colloid science lies in the importance of: Particle size Particle shape and flexibility Surface chemical and electrical properties The particles in a colloidal dispersion are sufficiently large for a well-defined surface of separation, an interface, to exist between the particles and the medium 3.

Particle Size The particle size distribution PSD directly affects the bioavailability of active pharmaceutical ingredients APIs and the safety of intravenous lipid emulsions.